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石蕊號：1393-92-6
英文名稱：Litmus；Tournesol；Turnsole；Laccamusica
其他名稱：石蕊指示劑
號：1393-92-6
相對分子質量：～3300
級別：IND
分光光度試驗：合格
PH ：4.5(紅)～8.3(藍)
性狀(以下信息僅供參考)：藍色粉末或塊狀。主要成分為石蕊素(AzoliTmus)和紅石蕊精(EryThro-liTmin)的堿金屬化合物。部分溶于水和乙醇而呈藍色。加酸則溶液變紅，加過量堿則溶液又變藍。
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)酸堿指示劑。制備石蕊試紙。培養基染色
保存：RT，避光。保質期5年 客戶根據石蕊號：1393-92-6 性質、化學式、分子式、結構式、比重、密度、號、沸點、熔點、水溶性、MSDS、用途、作用、規格包裝、性狀、注意事項、英文名、別稱、純度、級別等情況，本產品化學性質穩定，運輸條件不苛刻，一般儲存在陰涼，干燥，通風良好的地方，遠離不相容的物質。保持容器密閉。
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Function : May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
Subunit : Interacts with PUM2, SNAPIN and CTNNB1. Interacts (via N-terminal region) with CTNND1.
Subcellular Location : Cytoplasm.
Tissue Specificity : Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
DISEASE : Fetal ovary and fetal testis (at protein level).
Similarity : Belongs to the nanos family.
Contains 1 nanos-type zinc finger.
Database links : UniProtKB/Swiss-Prot: Q8WY41.2
英文名稱 Anti-NOBOX
中文名稱 同源盒蛋白NOBOX抗體
別 名 Homeobox protein NOBOX; Nobox; NOBOX Oogenesis Homeobox; NOBOX_HUMAN; OG-2; OG2; Og2x; POF5; TCAG_12042.
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep
產品類型 一抗
研究領域 發育生物學 干細胞 轉錄調節因子 表觀遺傳學
蛋白分子量 predicted molecular weight: 74kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human NOBOX (251-350aa)
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 Early ovarian folliculogenesis is characterized by the breakdown of germ cell clusters and formation of primordial follicles. The cessation of ovarian function under the age of 40 years results in premature ovarian failure (POF) and is accompanied by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. 1% of all women are affected by POF, and mutations in a few genes, including inhibin? fsh receptor and the LH/choriogonadotropin receptor have been linked to POF. In addition, several germ cell specific genes and downstream transcription factors are thought to play and important role in human oogenesis. NOBOX (newborn ovary homeobox gene), an ooctye-specific homeobox gene, is a critical protein involved in early folliculogenesis. Missense mutations have been shown to cause nonsyndromic ovarian failure by disrupting the NOBOX proteins ability to bind to NOBOX DNA-binding element (NBE), and thereby inhibiting its regulation of Pou5f1 and GDF-9. NOBOX expression in the ovary is oocyte specific, but it shows expression in adult testis and pancreas as well.
Function : Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.
Subcellular Location : Nucleus.
Tissue Specificity : Expressed in ovaries, testes and pancreas. Expressed within all stages of the adult female germline, from primordial follicles through to MII oocytes.
DISEASE : Defects in NOBOX are the cause of premature ovarian failure type 5 (POF5) [MIM:611548]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Similarity : Contains 1 homeobox DNA-binding domain.
Database links : UniProtKB/Swiss-Prot: O60393.4
