背景介紹：Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
別名：BBC 2; BBC2; BBC6; Bcl 2 Antagonist of Cell Death; Bcl 2 Binding Component 6; BCL X / BCL 2 Binding Protein; BCL X Binding Protein; Bcl XL/Bcl 2 Associated Death Promoter; Bcl-2-like protein 8; Bcl2 antagonist of cell death; BCL2 antagonist of cell death protein; BCL2 associated agonist of cell death; Bcl2 Associated Death Promoter; BCL2 binding component 6; BCL2 binding protein; Bcl2 Like 8 Protein; Bcl2-L-8; BCL2L8; BclXL; Proapoptotic BH3 Only Protein; BAD_HUMAN; Bcl-2-binding component 6.
相關(guān)死亡促進(jìn)因子Bad抗體,Anti-Bad抗體簡(jiǎn)單介紹：
產(chǎn)品編號(hào)：BYK-0892R
英文名稱：Anti-Bad
中文名稱：相關(guān)死亡促進(jìn)因子Bad抗體
產(chǎn)品規(guī)格：50ul；100ul；200ul；1ml，*
抗體來(lái)源 Rabbit or Mouse
克隆類型 Polyclonal or Monoclonal
交叉反應(yīng)、產(chǎn)品應(yīng)用 （具體交叉反應(yīng)與產(chǎn)品應(yīng)用請(qǐng)或添加客服直接索取）
性 狀 Lyophilized or Liquid
濃 度 1mg/ml
相關(guān)死亡促進(jìn)因子Bad抗體,Anti-Bad抗體產(chǎn)品信息：
博研生物小課堂：
常用激光器對(duì)應(yīng)熒光素的選擇：
藍(lán)色激光器熒光素（488nm）：Alexa Fluor 488、FITC、PerCP、PerCP-Cy5.5、PE、PE-Cy5.5、PE-Cy5、PE-Cy7
紅色激光器熒光素（633nm）：APC、Cy5、APC-Cy5.5、APC-Cy7、Alexa Fluor 647
黃色激光器熒光素（561nm）：PE、PE-Cy5.5、PE-Cy5、PE-Cy7、Cy3、Alexa Fluor 555、Alexa Fluor 594
抗體（antibody,Ab）：是指由漿細(xì)胞（PC）合成和分泌的，能與Ag進(jìn)行特異性結(jié)合的糖蛋白。
免疫球蛋白（immunoglobulin,Ig）: 具有抗體活性，或者在結(jié)構(gòu)上與Ab 相似的球蛋白。抗體是一類免疫球蛋白。
抗體是機(jī)體對(duì)抗原物質(zhì)產(chǎn)生免疫應(yīng)答的重要產(chǎn)物,具有各種免疫功能,主要存在于動(dòng)物的血液(血清)、淋巴液、組織液及其它外分泌液中,因此將抗體介導(dǎo)的免疫稱為體液免疫(humoral immunity)。
相關(guān)死亡促進(jìn)因子Bad抗體,Anti-Bad抗體相關(guān)產(chǎn)品：
Anti-MCR/NR3C2 鹽皮質(zhì)激素受體抗體
Anti-GSS/Glutathione Synthetase *合成酶抗體
Anti-OLFM3/Optimedin 嗅球蛋白3抗體
Anti-MPO/c-ANCA 髓過(guò)氧化物酶抗體
Anti-MAGOH 增殖相關(guān)蛋白MAGOH抗體
Anti-M-RAS/Mras 原癌基因M-ras抗體
Anti-Mouse IgA 兔抗小鼠IgA抗體
Anti-SLCO3A1/OATP-D 可溶性載質(zhì)轉(zhuǎn)運(yùn)蛋白3A1抗體
Anti-Moesin 膜突蛋白抗體
Anti-MOG 髓鞘少樹突膠質(zhì)細(xì)胞糖蛋白抗體
Anti-Beta-2-MG(B2E5) β2微球蛋白抗體(單抗)
Anti-MMP-12 基質(zhì)金屬蛋白酶-12抗體
Anti-HS6ST1 硫酸乙酰肝素6腦苷脂轉(zhuǎn)硫酸酶1抗體
