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L755,507, CRISPR Editing Enhancer
A potent and selective β3 adrenergic receptor partial agonist, can enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
| Catalog No. | Unit | Price | Qty |
|---|---|---|---|
| M60237-2s | 2 mg solid |
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Product Information M60237-2s代理，L755,507, CRISPR Editing Enhance
| Molecular Weight: | 584.73 |
| Formula: | C30H40N4O6S |
| Purity: | ≥ 98% |
| CAS#: | 159182-43-1 |
| Solubility: | DMSO up to 100 mM |
| Chemical Name: | (S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide |
| Storage: | Powder: 4oC 1 year DMSO: 4oC 3 month -20oC 1 year |
Biological Activity:M60237-2s代理，L755,507, CRISPR Editing Enhance
L-755,507 was previously characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 ~0.43 nM. It has > 1000 fold selectivity overβ1- and β2-adrenoceptors (EC50 ~ 580 nM and >10000 nM for β1- and β2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). In a recent study, L-755,507 was identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
How to Use:
In vitro: L-755,507 was used at 1-5 ?M final concentration in various in vitro assays.
In vivo: L-755,507 stimulates metabolic rate by 30% after acute bolus intravenous administration of 0.1 mg/kg to rhesus monkeys.
Reference:M60237-2s代理，L755,507, CRISPR Editing Enhance
- 1. Fisher MH, et al. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. (1998) J Clin Invest.101(11):2387-93.
- 2. Parmee ER, et al. Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist. (1998) Bioorg Med Chem Lett. 8(9):1107-12.
- 3. Yu C, et al. Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells. (2015) Cell Stem Cell.16(2):142-7.
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