3,3-二氨基聯苯胺四鹽酸鹽無水物號：7411-49-6   
英文名稱：DAB·4HCL；3，3-Diamonobenzidine tetrahydrchloride；3,3',4,4'-Biphenyltetramine tetrahydrochloride    
其他名稱：3,4,3′,4′-四氨基聯苯四鹽酸鹽；硒試劑；3,3-二氨基聯苯胺鹽酸鹽；(1,1'-聯苯)-3,3'4,4'-四胺四鹽酸鹽；鹽酸-3,3′-二氨基聯苯胺   
號：7411-49-6   
C12H14N4?4HC1=360.11   
級別：Reagent Grade   
含量：≥98.0%    
Solubility (5%, Water)：合格   
性狀(以下信息僅供參考)：淡棕色粉末或灰色或白色結晶粉末。中度溶于水，不溶于大多數有機溶劑。熔點300℃   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)光度法測定硒的試劑。過氧化酶HRP底物，適用于免疫印跡和免疫組織化學染色程序。該底物能產生一種不溶性棕色的末端產物。肉眼或可見光下就可觀察。。過氧化酶染色應用：在聚丙烯酰胺凝膠上區分兩種分枝桿菌過氧化輕酶（mycobacterial catalase）；在聚丙烯酰胺凝膠上血紅色蛋白的專一指示劑。   
保存：RT，避光3,3-二氨基聯苯胺四鹽酸鹽無水物號：7411-49-6儲存條件：
避光、干燥陰涼處封閉貯存,嚴禁與有毒、有害物品混放、混運。本品為非危險 產品可按一般化學品運輸,輕搬動輕放,防止日曬、雨淋！受熱、受潮、受光后易喪失活力,保存期短,因此貯存和運輸條件比較苛刻。
運輸：汽車運輸、EMS郵政快遞，申通快遞等， 款到上海3天內發貨；
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存儲：應貯存在干燥清潔避光的環境中，嚴禁與有毒物質混放，以免污染（保質期為兩年）。
主要優級純、分級純和化學純3種：
（1）優級純（GR：Guaranteed reagent），又稱一級品或保證試劑，99.8%，這種試劑純度Z高，雜質含量Z低，適合于重要精密的分析工作和科學研究工作，使用綠色瓶簽。
（2）分析純（AR），又稱二級試劑，純度很高，99.7%，略次于優級純，適合于重要分析及一般研究工作，使用紅色瓶簽。
（3）化學純（CP），又稱三級試劑，≥ 99.5%，純度與分析純相差較大，適用于工礦、學校一般分析工作。使用藍色（深藍色）標簽。
（4）實驗試劑（LR：Laboratory reagent），又稱四級試劑。
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Function : Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
Subunit : Isoform 1, isoform 2 and isoform 4 form homo- and heterodimers. Interacts with NECAB3 and HMGA2 (By similarity). Isoform 1 interacts with CDC20, CTNB1, MAD1L1, MAPK, NEK11, NPM1, NDC80, PCNT and SGOL1. Isoform 1 interacts with STK3/MST2 (via SARAH domain) and SAV1 (via SARAH domain). Isoform 1 and isoform 2 interact with MAD2L1. Isoform 1 and isoform 4 interact with PPP1CA and PPP1CC.
Subcellular Location : Isoform 1: Nucleus. Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome, centromere, kinetochore. Chromosome, centromere (By similarity). Note=STK3/MST2 and SAV1 are required for its targeting to the centrosome. Co-localizes with SGOL1 and MAD1L1 at the kinetochore. Not associated with kinetochore in the interphase but becomes associated with it upon the breakdown of the nuclear envelope. Has a nucleolar targeting/ retention activity via a coiled-coil domain at the C-terminal end.
Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. <> Isoform 4: Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Predominantly brnuclear.
Tissue Specificity : Isoform 1 and isoform 2 are expressed in peripheral blood T-cells and a wide variety of transformed cell types. Isoform 1 and isoform 4 are expressed in the testis. Up-regulated in various cancer cell lines, as well as primary breast tumors.
Post-translational modifications : Activated by autophosphorylation. Protein phosphatase 1 represses autophosphorylation and activation of isoform 1 by dephosphorylation. Phosphorylation by STK3/MST2 is necessary for its localization to the centrosome.
Similarity : Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
Contains 1 protein kinase domain.
Database links : UniProtKB/Swiss-Prot: P51955.1
英文名稱  Anti-Nucleoprotein TPR
中文名稱  核蛋白易位啟動子區域TPR抗體
別    名  Nucleoprotein TPR; tpr; TPR_HUMAN; translocated promoter region (to activated MET oncogene).
濃    度  1mg/1ml
規 格  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit
產品類型  一抗   
研究領域  腫瘤 細胞生物 免疫學 信號轉導 細胞周期蛋白 激酶和磷酸酶 
蛋白分子量  predicted molecular weight: 260kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human Nucleoprotein TPR
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用   ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or