4，4-雙（二甲氨基）硫代二苯甲酮號(hào)：1226-46-6   
英文名稱(chēng)：Thiomichler's ketone；4,4′-Bis(dimethylamino)thiobenzophenone；4,4′-Tetramethyldiaminothiobenzophenone

；p,p′-Tetramethyldiaminoth- iobenzophenone   
其他名稱(chēng)：4,4-雙(二甲氨基)硫代二甲酮；硫代米氏酮；4,4′-四甲基二氨基硫代二苯甲酮；對(duì),對(duì)′-四甲基二氨基二苯硫酮；4,4′-雙

(二甲氨基)硫代二苯甲酮；4,4'-雙二甲氨基硫代二苯甲酮；硫代米蚩酮；雙[4-(二甲氨基)苯基]甲硫酮；4,4'-雙(二甲胺基)硫代苯甲酮

  
號(hào)：1226-46-6   
C17H20N2S=284.42   
級(jí)別：AR   
熔點(diǎn)：201～206℃   
性狀(以下信息僅供參考)：深紅色結(jié)晶。易溶于熱乙醇、苯和乙酸，溶于鹽酸中呈深藍(lán)色，溶于方中呈深紅色，不溶于石油醚和水。

 
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)測(cè)定金、鈀、鉑、汞、銀、銅的光度試劑。   
保存：RT

4，4-雙（二甲氨基）硫代二苯甲酮號(hào)：1226-46-6儲(chǔ)存條件：
避光、干燥陰涼處封閉貯存,嚴(yán)禁與有毒、有害物品混放、混運(yùn)。本品為非危險(xiǎn) 產(chǎn)品可按一般化學(xué)品運(yùn)輸,輕搬動(dòng)輕放,防止日曬、雨淋！受熱、受潮、受光后易喪失活力,保存期短,因此貯存和運(yùn)輸條件比較苛刻。
運(yùn)輸：汽車(chē)運(yùn)輸、EMS郵政快遞，申通快遞等， 款到上海3天內(nèi)發(fā)貨；
售后：如您對(duì)我們的產(chǎn)品服務(wù)及技術(shù)指標(biāo)有特殊要求，請(qǐng)及時(shí)通知我方。
存儲(chǔ)：應(yīng)貯存在干燥清潔避光的環(huán)境中，嚴(yán)禁與有毒物質(zhì)混放，以免污染（保質(zhì)期為兩年）。
4，4-雙（二甲氨基）硫代二苯甲酮號(hào)：1226-46-6主要優(yōu)級(jí)純、分級(jí)純和化學(xué)純3種：
（1）優(yōu)級(jí)純（GR：Guaranteed reagent），又稱(chēng)一級(jí)品或保證試劑，99.8%，這種試劑純度Z高，雜質(zhì)含量Z低，適合于重要精密的分析工作和科學(xué)研究工作，使用綠色瓶簽。
（2）分析純（AR），又稱(chēng)二級(jí)試劑，純度很高，99.7%，略次于優(yōu)級(jí)純，適合于重要分析及一般研究工作，使用紅色瓶簽。
（3）化學(xué)純（CP），又稱(chēng)三級(jí)試劑，≥ 99.5%，純度與分析純相差較大，適用于工礦、學(xué)校一般分析工作。使用藍(lán)色（深藍(lán)色）標(biāo)簽。
（4）實(shí)驗(yàn)試劑（LR：Laboratory reagent），又稱(chēng)四級(jí)試劑。
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Subunit : Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID. Directly interacts with MEN1. Interacts with HIF1AN.
Subcellular Location : Nucleus. Cytoplasm. Note=Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
Post-translational modifications : While translation occurs, the particular unfolded structure after the GRR repeat promotes the generation of p50 making it an acceptable substrate for the proteasome. This process is known as cotranslational processing. The processed form is active and the unprocessed form acts as an inhibitor (I kappa B-like), being able to form cytosolic complexes with NF-kappa B, trapping it in the cytoplasm. Complete folding of the region downstream of the GRR repeat precludes processing.
Phosphorylation at 'Ser-903' and 'Ser-907' primes p105 for proteolytic processing in response to TNF-alpha stimulation. Phosphorylation at 'Ser-927' and 'Ser-932' are required for BTRC/BTRCP-mediated proteolysis.
Polyubiquitination seems to allow p105 processing.
S-nitrosylation of Cys-61 affects DNA binding.
The covalent modification of cysteine by 15-deoxy-Delta12,14-prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-4，4-雙（二甲氨基）硫代二苯甲酮號(hào)：1226-46-6palmitoylation.
Similarity : Contains 7 ANK repeats.
Contains 1 death domain.
Contains 1 RHD (Rel-like) domain.
英文名稱(chēng)  Anti-Phospho-NFKB1(Ser907)
中文名稱(chēng)  磷酸化細(xì)胞核因子p50/k基因結(jié)合核因子抗體