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藍V號：3536-49-0   
英文名稱：Patent Blue V；Patent Blue V calcium salt；Acid Blue 3 calcium salt；Acid Blue V calcium salt；Food Blue 5；Patent Blue V   
其他名稱：C.I.藍V；酸性藍3 ；蘭V；藍V號鈣鹽；藍五號鈣鹽；酸性湖藍Ⅴ；酸性藍Ⅴ   
號：3536-49-0   
C27H31N2O7S2 · 0.5Ca=579.71   
級別：AR   
含量：≥85.0%   
性狀(以下信息僅供參考)：暗紅青蓮色或深藍紫色粉末或顆粒。易溶于水呈藍色，微溶于乙醇呈藍綠色。遇濃硫酸顯棕橄欖黃色，稀釋顯深黃至綠色。水溶液加氫氧化鈉不變色，加熱則呈深紫色   
用途：本品僅供科研，不得用于其它用途。(以下用途僅供參考)酸堿指示劑，pH 0.8(黃)～3.0(藍)。氧化還原指示劑(黃綠色～橙色)。螺旋體和活體染色   
保存：RT  客戶根據藍V號：3536-49-0性質、化學式、分子式、結構式、比重、密度、號、沸點、熔點、水溶性、MSDS、用途、作用、規格包裝、性狀、注意事項、英文名、別稱、純度、級別等情況，本產品化學性質穩定，運輸條件不苛刻，一般儲存在陰涼，干燥，通風良好的地方，遠離不相容的物質。保持容器密閉。
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temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 The Sp transcription factor family includes Sp1, Sp2, Sp3 (SPR-2) and Sp4 (SPR-1). Sp transcription factors share similar structures but do not share simi-lar functions. All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the C-terminus. Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes. Sp1, Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not. Sp2 only weakly binds to GT boxes. Sp1, Sp2 and Sp3 are ubiquitously expressed, while Sp4 is abundantly expressed in brain with limited expression in other tissues. Sp1 and Sp3, but not Sp2 or Sp4, interact with E2, a regulatory element for the ∫4 subunit of neuronal nicotinic acetylcholine receptors. Sp3 is the only Sp member to inhibit Sp1 and Sp4 media
Function : Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.
Subunit : Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a.
Subcellular Location : Nucleus. Nucleus > PML body. Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
Tissue Specificity : Ubiquitously expressed.
Post-translational modifications : Not glycosylated.
Acetylated by histone acetyltransferase p300, deacetylated by HDACs. Acetylation/deacetylation states regulate transcriptional activity. Acetylation appears to activate transcription. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. In vitro, C(18)-ceramides, but not C(16)-ceramides, increase the interaction of HDAC1 with SP3 and enhance the deacetylation of SP3 and the subsequent repression of the TERT promoter.
Sumoylated on all isoforms. Sumoylated on 2 sites in longer isoforms with Lys-551 being the major site. Sumoylation at this site promotes nuclear localization to the nuclear periphery, nuclear dots and PML nuclear bodies. Sumoylation on Lys-551 represses the transactivation activity, except for the largest isoform, L-Sp3, which has little effect on transactivation. Alternate sumoylation and acetylation at Lys-551 also control transcriptional activity.
Similarity : Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: Q02447.3
英文名稱  Anti-SP6
中文名稱  轉錄因子SP6抗體
別    名  MGC119665; Epfn; EPIPROFIN; KLF14; Krueppel-like factor 14; MGC119662; MGC119663; MGC119664; Sp6; Sp6 transcription factor; SP6_HUMAN; Transcription factor Sp6.
濃    度  1mg/1ml
規 格  0.1ml/100μg  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat, Dog, Pig, Cow, Horse
產品類型  一抗   
研究領域  細胞生物 神經生物學 細胞周期蛋白 轉錄調節因子 鋅指蛋白 表觀遺傳學 
蛋白分子量  predicted molecular weight: 40kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human SP6
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4