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蜜二糖號：585-99-9   
英文名稱：Melibiose；6-O-α-D-Galactopyranosyl-D-glucose；D-(+)-Melibiose    
其他名稱：D(+)-密二糖一水；α-D-蜜二糖；6-O-α-D-吡喃半乳糖基-D-葡萄糖；D(+)-蔗糖八乙酸酯    
號：585-99-9    
C12H22O11=342.3   
級別：BR   
含量：≥98.0% (HPLC)    
熔點：176～181℃   
性狀(以下信息僅供參考)：白色或類白色粉末，由水或乙醇的稀溶液中制得結晶。熔點84～85℃。每克溶于0.4ml水、8.5ml甲醇或220ml無水乙醇。用稀酸水解得到葡萄糖及半乳糖；能還原費林溶液。甜度約為蔗糖的1/3   
用途：本品僅供科研，不得用于其它用途。   
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產品類型  一抗  磷酸化抗體  
研究領域  細胞生物 發(fā)育生物學 神經(jīng)生物學 信號轉導 
蛋白分子量  predicted molecular weight: 148kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthesised phosphopeptide derived from human SynGAP around the phosphorylation site of Ser836
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. SynGAP (for synaptic GTPase activating protein), a novel synaptic RasGAP, is a brain-specific protein abundant in the cortex, hippocampus and olfactory bulb. SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins. It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors. SynGAP may be involved in the regulation of BDNF as well as Ras signaling. Its activity is inhibited by phosphorylation by CaMKII, which could result in the activation of the MAP kinase pathway.
Function : Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
Subunit : Interacts KLHL17, CAMK2A and CAMK2B. Interacts with MPDZ.
Post-translational modifications : Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption.
DISEASE : Defects in SYNGAP1 are the cause of mental retardation autosomal dominant type 5 (MRD5) [MIM:612621]. Mental retardation is characterized by significantly sub-average general inlectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD5 patients show global developmental delay with delayed motor development, hypotonia, moderate-to-severe mental retardation, and severe language impairment. Autism can be present in some patients.
Similarity : Contains 1 C2 domain.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.
Database links : UniProtKB/Swiss-Prot: Q96PV0.4 huamn
蜜二糖號：585-99-9英文名稱  Anti-shevelled 2
中文名稱  蓬亂蛋白2抗體
別    名  Dishevelled 2 (homologous to Drosophila dsh); Dishevelled dsh homolog 2; Dishevelled-2; Dishevelled2; DSH homolog 2; DVL 2; Dvl2; DVL2_HUMAN; Segment polarity protein dishevelled homolog DVL 2; Segment polarity protein dishevelled homolog DVL-2; Segment polarity protein dishevelled homolog DVL2.
濃    度  1mg/1ml
規(guī) 格  0.1ml/100μg  0.2ml/200μg
抗體來源  Rabbit 
克隆類型  polyclonal
交叉反應  Human, Mouse, Rat
產品類型  一抗   
研究領域  細胞生物 免疫學 信號轉導 干細胞 細胞凋亡 
蛋白分子量  predicted molecular weight: 81kDa
性    狀  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human shevelled 2
亞    型  IgG
純化方法  affinity purified by Protein A
儲 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蠟切片需做抗原修復）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存條件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximay 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008].
Function : Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and tran