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D-(+)-蘋果酸號:636-61-3
英文名稱:D(+)-Malic acid;D-Hydroxysuccinic acid;(R)-Hydroxybutanedioic acid
其他名稱:(R)-羥基丁二酸;D-蘋果酸;R-羥基丁二酸;R-(+)-蘋果酸
號:636-61-3
C4H6O5=134.09
級別:試劑級
含量:≥99%
比旋光度:+1.6~+2.6°
性狀(以下信息僅供參考):白色結晶或粉末。易溶于水和乙醇。
用途:本品僅供科研,不得用于其它用途。
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產品介紹 SCDGFB (Spinal cord derived growth factor B) is a member of the plaet derived growth factor family. It only forms homodimers and does not dimerize with the other three family members. It is a potent mitogen for cells of mesenchymal origin. It is activated by proteolytic cleavage and this active form acts as a specific ligand for beta plaet derived growth factor receptor. It is released by plaets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. It induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.
Function : Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity).
Subunit : Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.
Subcellular Location : Secreted. Note=Released by plaets upon wounding.
Tissue Specificity : Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.
Post-translational modifications : Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.
Similarity : Belongs to the PDGF/VEGF growth factor family.
Contains 1 CUB domain.
Database links : UniProtKB/Swiss-Prot: Q9GZP0.1
英文名稱 Anti-SMAGP
中文名稱 小細胞跨膜糖化蛋白抗體
別 名 hSMAGP; small cell adhesion glycoprotein; SMAGP_HUMAN; small cell transmembrane and glycosylated protein; small transmembrane and glycosylated protein.
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human
產品類型 一抗
研究領域 腫瘤 免疫學 細胞粘附分子 腫瘤細胞生物標志物
蛋白分子量 predicted molecular weight: 11kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human SMAGP
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500
(石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.
Function : May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.
Subcellular Location : Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions. Detected on cytoplasmic membranes in undifferentiated tumors.
Tissue Specificity : Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level).
Post-translational modifications : O-glycosylated. The O-glycan is modified with sialic acid residues.
Similarity : Belongs to the SMAGP family.
Database links : UniProtKB/Swiss-Prot: Q0VAQ4.1
英文名稱 Anti-Syncytin 1/HERV
中文名稱 合胞素1抗體
別 名 Endogenous retrovirus group W member 1; env; Env-W; Envelope polyprotein gPr73; Enverin; ENW1_HUMAN; ERVW; ERVW-1; Gp24; Gp50; HERV-7q Envelope protein; HERV-W envelope protein; HERVW; SU; Syncytin 1; Syncytin; Syncytin-1; TM; Transmembrane protein.
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human
產品類型 一抗
研究領域 細胞生物 微生物學 細菌及
蛋白分子量 predicted molecular weight: 33/58kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Syncytin 1
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蠟切片需做抗原修復)
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