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β-谷甾醇號:83-46-5
英文名稱:β-Sitosterol;24-Ethylcholest-5-en-3beta-ol;alpha-Dihydrofucosterol;22,23-Dihydrostigmasterol;24beta-Ethylcholesterol;5-Stigmasten-3beta-ol
其他名稱:β-谷固醇;(3β)-豆甾-5-烯-3-醇;β-植物甾醇;β-植物固醇;麥固醇
號:83-46-5
C29H50O=414.71
級別:精制級
純度:≥98.0%
性狀(以下信息僅供參考):白色粉末或夾帶塊狀結晶。一種植物中常見的甾醇,可從多種植物油中分離。溶于方、熱乙醇、乙迷,微溶于冷乙醇,幾乎不溶于水
用途:本品僅供科研,不得用于其它用途
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產品介紹 Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn-SOD/SOD-1), mitochondrial manganese SOD (Mn-SOD/SOD-2) and extracellular Cu, Zn-SOD (EC-SOD/SOD-3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2, is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin-binding multimer of disulfide-linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperone for superoxide dismutase (CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
Function : Delivers copper to copper zinc superoxide dismutase (SOD1).
Subunit : Homodimer, and heterodimer with SOD1. Interacts with COMMD1. Interacts with XIAP/BIRC4.
Subcellular Location : Cytoplasm.
Tissue Specificity : Ubiquitous.
Post-translational modifications : Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241.
Similarity : In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.Contains 1 HMA domain.
Database links : UniProtKB/Swiss-Prot: O14618.1
英文名稱 Anti-phospho-STAT5a(Ser726)
β-谷甾醇號:83-46-5中文名稱 磷酸化信號轉導和轉錄激活因子5a抗體
別 名 STA5A_HUMAN; STAT5A(phospho S726); Mammary gland factor; Mammary gland factor; MGF; MGF; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5A; STAT 5; STAT 5A; STAT5; STAT5A.
濃 度 1mg/1ml
規 格 0.1ml/100μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep
產品類型 一抗 磷酸化抗體
研究領域 染色質和核信號 信號轉導 表觀遺傳學
蛋白分子量 predicted molecular weight: 91kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human STAT5a around the phosphorylation site of Ser726
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用 WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 Stat 5a protein is a transcription factor activated by hormone and cytokines. Two highly related, but distinct Stat 5 genes (Stat 5a and Stat 5b) were identified in mouse. The amino acid sequences of Stat 5a and Stat 5b show 96% sequence similarity, and both proteins are co expressed in most tissues of both virgin and lactating mice. However, differential accumulation of Stat 5a and Stat 5b mRNA has been reported for both muscle and mammary tissue. Stat 5a is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.
Function : Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
Subunit : Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7. Interacts with ERBB4.
Subcellular Location : Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
Post-translational modifications : Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 at Tyr-694.
Similarity : Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.
Database links : UniProtKB/Swiss-Prot: P42229.1
英文名稱 Anti-phospho-STAT5a(Ser780)
中文名稱 磷酸化信號轉導和轉錄激活因子5a抗體
別 名 STAT5A(Phospho-Ser780); STAT5A(phospho S780); Mammary gland factor; Mammary gland factor; MGF; MGF; Signal transducer and activator of transcription 5A; Signal transducer and activator of transcription 5A; STA5A_HUMAN; STAT 5; STAT 5A; STAT5; STAT5A.
濃 度 1mg/1ml
規 格 0.1ml/100μg
抗體來源 Rabbit
克隆類型 polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Horse
產品類型 一抗 磷酸化抗體
研究領域 染色質和核信號 信號轉導 表觀遺傳學
蛋白分子量 predicted molecular weight: 91kDa
性 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human STAT5a around the phosphorylation site of Ser780
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蠟切片需做抗原修復)
not yet tested in other applications.
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