【中文名稱】：BRCA1 Polyclonal Antibody?

【英語名稱】：BRCA1 Polyclonal Antibody

【產品類型】：一抗

【供應商】：Abbkine

【產品貨號】：ABP50789

【產品規格】：30ul/100ul/200ul

【背景資料】：BRCA1encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein(BRCA1, DNA repair associated)combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximay 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified
蛋白別名為：BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53;基因ID為：672；蛋白質ID:P38398

【應用類型】：WB，IHC-p，IF，ELISA
補充：*的抗體稀釋比例需要基于客戶實驗進行優化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:5000. Not yet tested in other applications.

【免疫原】：合成多肽：human BRCA1 around the non-phosphorylation site of S1423.

【來源宿主】：兔

【反應性】：人，大鼠

【保存建議】：廠家*藍冰運輸.在發貨后能在-20℃保存1年.為zui大限度的避免損失，請在打開管蓋之前融化抗體并離心.我們建議使用前分裝以避免反復凍融.
本產品為液體形式,溶解于PBS緩沖液中，含50%甘油，0.5%BSA和0.02%*.

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產品標簽:BRCA1 (phospho Ser1423) Polyclonal Antibody，BRCA1 Polyclonal Antibody